Evidence-based assessment and application of prognostic markers: The long way from single studies to meta-analysis

Willi Sauerbrei, Richard Riley & Doug Altman
Background: The identification and assessment of prognostic markers constitutes one of the major tasks in clinical research. Despite huge research effort, the prognostic value of most traditional factors under discussion is uncertain and the usefulness of many specific markers is still unproven. Results[for full text, please go to the a.m. URL]