Association between generic substitution of valproate and therapeutic modification of antiepileptic therapy – a cohort study with time-dependent exposure utilizing the DAPI ambulatory drug claims data

Katrin Schuessel, Stephanie Von Klot & Martin Schulz
Introduction/background: Generic substitution of antiepileptic medicines, especially of modified release products, is discussed controversially. All the more in Germany, since rebate contracts between pharmaceutical manufacturers and statutory health insurance (SHI) funds associated with compulsory[for full text, please go to the a.m. URL]