PTGS1 and PTGS2 polymorphisms, fatty acid intake, and risk of colon and rectal cancer

Nina Habermann, Martha L. Slattery, Elizabeth M. Poole, Liren Xiao, Rachel Galbraith, David Duggan, Richard J. Kulmacz, Bette J. Caan, Lisl Koepl, Anne Coghill, Karen W. Makar, Abbie Lundgreen, John Potter & Cornelia Ulrich
Introduction: Inflammation plays a major role in colorectal cancer. COX-1 and COX-2 convert n-3 and n-6 fatty acids into prostaglandins which have anti- and pro-inflammatory effects, respectively [ref:1]. We examined potential interactions between polymorphisms in PTGS1 (COX-1) and PTGS2 (COX-2)[for full text, please go to the a.m. URL]