Tumour and fibroblast cell lines as an in vitro-tumour model system for HNSCC: Efficacy analysis of kinase inhibitors in combination with irradiation

Annette Affolter, Wolf J. Mann & Jürgen Brieger
Introduction: The emergence of radioresistance has become one of the most significant issues in the treatment of head and neck squamous cell carcinomas. We have previously demonstrated that the radiation-induced activation of MAP kinase ERK and subsequently VEGF might cause decreased radiosensitivity[for full text, please go to the a.m. URL]