Promoter methylation of Cyclin A1 is associated with Human Papillomavirus 16 induced Head and Neck Squamous Cell Carcinoma independently of p53 mutation

Daniel Weiss, Türker Basel, Florian Sachse & Claudia Rudack
Several risk factors exist on the gene level for the development of Head and Neck Squamous Cell Carcinoma (HNSCC). Besides amplification of epidermal growth factor receptor (EGFR) and loss of heterozygosity on 9p or 3p infection with HPV16 and promoter methylation are important for carcinogenesis in[for full text, please go to the a.m. URL]