Genotoxic effects of nicotine in human nasal mucosa miniorgan-cultures

Gudrun Friehs, Christian Ginzkey, Rudolf Hagen & Norbert Kleinsasser
Introduction: Tobacco ingredients are risk factors for carcinogenesis in the upper aerodigestiv tract. DNA-damage induced by nicotine was detected in different human tissues, e. g. tonsillar tissue, salivary glands and nasal mucosa. Mini organ cultures of nasal mucosa (MOC) demonstrate an adequate model[for full text, please go to the a.m. URL]