High-frequency stimulation of the subthalamic nucleus counteracts gene regulation of MHC class II-related genes in a rat model of Parkinson's disease

B. Grieb, C.K.E. Moll, G. Engler, T. Streichert, M. Westphal, A.K. Engel & W. Hamel
Objective: Changes in neuronal activity are thought to underlie the development of symptoms in neurodegenerative diseases such as Parkinson's disease (PD). Adaptive neuronal responses to therapeutic interventions such as deep brain stimulation (DBS), assessed on the level of gene expression changes[for full text, please go to the a.m. URL]
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