Hyperactivity of the subthalamic nucleus in the rat 6-hydroxydopamine Parkinson model is reduced by deep brain stimulation of the pedunculopontine nucleusM. Alam, K. Schwabe, H.E. Heissler & J.K. Krauss
Objective: The pedunculopontine nucleus (PPN) is used as a target for deep brain stimulation (DBS) to treat severe and pharmaceutical-resistant postural instability and freezing in Parkinson’s disease (PD). It has been shown that lesions of the PPN reverse the increased firing rate of neurons[for full text, please go to the a.m. URL]
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