Inflammation-induced breakdown of intestinal epithelial barrier functions is blocked by increased cAMP-levels in enterocytes

Sven Flemming, Martin Schick, Michael Meir, Christoph-Thomas Germer & Nicolas Schlegel
Introduction: Intestinal epithelial barrier breakdown and consecutive bacterial translocation promotes inflammatory response in septic patients. Convincing therapeutic approaches to stabilize intestinal epithelial barrier properties are still missing. Therefore we tested here whether inhibition of phosphodiesterase-4[for full text, please go to the a.m. URL]