Reversal of cortical spreading ischemia induced vasoconstriction of isolated rat MCA by T-type Ca2+ channel inhibition

U. Lindauer, H. Baumgärtner, M. Schreiber, S. Pinkernell & B. Meyer
Objective: During nitric oxide synthase (NOS) inhibition, cortical spreading depolarisation (CSD) can induce severe vasoconstriction (cortical spreading ischemia, CSI) [ref:1]. CSI can be modeled in the isolated middle cerebral artery (MCA) by application of combined extraluminal ion changes[for full text, please go to the a.m. URL]