Role of the microlesion effect (MLE) after DBS on simple and ballistic tasks in Parkinson's disease and Dystonia

A. Singh, S. Kammermeier, K. Boetzel & J.H. Mehrkens
Objective: Many patients undergoing DBS show an improvement of symptoms right after lead-implantation even before stimulation due to a so-called microlesion effect (MLE), the precise mechanism of which remains unknown. It is assumed that the MLE is caused by inactivation of neurons surrounding the electrode[for full text, please go to the a.m. URL]