The effects of high frequency stimulation of the subthalamic nucleus on mood: a role for the lateral habenula?

S.K.H. Tan, V.V. Visser-Vandewalle, T. Sharp, H. Clusmann, H.W.M. Steinbusch & Y. Temel
Objective: High frequency stimulation (HFS) of the subthalamic nucleus (STN) improves motor disability in Parkinson's disease. Despite sustained motor improvement, a substantial number of patients develop post-operative behavioural complications, including depression. Our previous studies demonstrated[for full text, please go to the a.m. URL]