In vitro 3D reconstitution of the mammalian spinal cord using murine embryonic stem cells

M. Niesche, A. Meinhardt, E. Tanaka, M. Kirsch & G. Schackert
Objective: Traumatic spinal cord injury (SCI) is a devastating illness with severe disability, major associated morbidities and poor feasibility of regeneration. In this project we wanted treat organotypic 3D neuroepithelial tubes from murine ES cells to accomplish patterning and spatial organization[for full text, please go to the a.m. URL]