IDH 1/2 mutations in astrocytomas WHO grade II: association with localization and seizure as initial symptom

F. Stockhammer, M. Misch, H.J. Helms, U. Lengler, F. Prall, A.V. Deimling & C. Hartmann
Objective: Seizures are the most common initial symptom in patients with low-grade gliomas and strongly depend on the site of the tumour. The majority of low-grade gliomas reveal mutations in the genes encoding isocitrate-dehydrogenase 1 (IDH1) or 2 (IDH2). These mutations are associated with metabolic[for full text, please go to the a.m. URL]