Influence of novel AQP1 promoter haplotypes on AQP1 expression, tumor edema as well as two-years survival in patients suffering from glioblastoma multiforme

N.E. Hindy, M. Adamzik, N. Lambertz, Y. Zhu, U. Sure & I.E. Sandalcioglu
Objective: Water channel proteins (AQP) are overexpressed in brain tumors, mediating cell proliferation and angiogenesis. We investigated the influence of two AQP1 promoter single nucleotide polymorphisms (-783C > G)/(-781C > T) defining novel AQP1 haplotypes on gene expression and their[for full text, please go to the a.m. URL]