Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to the increase of CD133+ cell population in human glioblastoma-derived cultures in lowered oxygen tension

U. Kahlert, D. Maciaczyk, M. Döbrössy, C.H. Herold-Mende, G. Nikkhah & J. Maciaczyk
Objective: Brain tumor stem-like cells (BTSC) are responsible for tumor initiation, propagation and resistance to standard therapies. Previous reports showed hypoxia-induced increase of BTSC expressing CD133 together with over-expression of other stem cell-related genes and more pronounced clonogenic[for full text, please go to the a.m. URL]