VEGFR-3 is upregulated in glioblastoma-derived endothelial cells and tumor cells under hypoxic conditions and is a mediator for tumor resistance

J. Thorsteinsdottir, J. Puymann, J.C. Tonn & C. Schichor
Objective: Under physiological conditions VEGFR-3 plays a role in early angiogenesis promoting vascular sprouting in embryos and is a key mediator for lymphangiogenesis in adults. Recent studies showed an increasing role of VEGFR-3 in tumorangiogenesis. Especially, in glioma, a grade-dependent expression[for full text, please go to the a.m. URL]