The Disintegrin-Metalloproteinase ADAM8 as a therapeutic target in highly invasive gliomas

J.W. Bartsch, U. Schlomann, S. Schieber, F. Dong, A. Pagenstecher & C. Nimsky
Objective: ADAMs are zinc-dependent metalloproteases with important roles in tumor cell growth, cell migration and tumor angiogenesis. We explored the functional role of a member of this family, ADAM8, in gliomas by generating U87 glioma cell lines with a knockdown of ADAM8 and pharmacological inhibition[for full text, please go to the a.m. URL]