Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model

T.M. Freiman, M.P. Rassner, J.M. Hebel, D.M. Altenm├╝ller, T.J. Feuerstein & J. Zentner
Objective: Pharmacological treatment of epilepsies is mainly limited due to side effects of systemically applied anticonvulsive agents in high doses. Moreover, some of most efficient substances cannot cross the blood-brain barrier. To overcome these limitations, we tested in an animal experimental animal[for full text, please go to the a.m. URL]