A combined treatment with temozolomide and artesunate yields an antagonistic antiproliferative effect on glioblastoma multiforme cells

G.K. Karpel-Massler, M.A. Westhoff, K.M. Debatin, C.R. Wirtz & M.E. Halatsch
Objective: As chemotherapy with temozolomide is far from providing satisfactory clinical outcomes for patients with glioblastoma multiforme, more efficient drugs and drug combinations are urgently needed. The anti-malarial artesunate was previously shown to exert a profound cytotoxic effect on various[for full text, please go to the a.m. URL]