Resveratrol induces apoptosis in GH3 pituitary adenoma cells of the rat

B. Voellger, A. Weise, E. Kirches, A.W. Wilisch-Neumann, J.H.T. Tapia-Perez, C. Mawrin & R. Firsching
Objective: Resveratrol is a phytoestrogen with various antiproliferatic and proapoptotic effects. One of the underlying mechanisms is downregulation of apoptosis inhibitors, such as Survivin. In human pituitary adenoma cells, Survivin expression is increased as compared to healthy pituitary gland tissue.[for full text, please go to the a.m. URL]