Involvement of neuronal phosphotyrosine signal adaptor N-Shc in the kainic acid-induced epileptiform activity

S. Baba, S. Kakizawa, K. Ohyama, K. Yasuda, T. Matuo, N. Mori & Izumi Nagata
BDNF-TrkB signaling is implicated in experimental seizure and epilepsy. However, the downstream signaling mechanism of epileptogenesis from TrkB receptor activation is still controversial and whether it progresses through the PLCγ, Shc, or both is unclear. Recent studies have demonstrated that[for full text, please go to the a.m. URL]