Targeting EGFRvIII-positive glioma cells using a novel natural killer cell chimeric antigen receptor type consisting of DAP12 and the single chain antibody variable fragment MR1-1

N. Müller, K. Töpfer, M. Cartellieri, G. Schackert & A. Temme
Objective: Natural killer cells (NK) are able to recognize and kill tumor cells with loss of HLA class I expression and concomitant decrease of HLA-E on their surface. However, most gliomas still express HLA class I, and NK cell reactivity against HLA I-negative solid tumors is blocked by inhibitory[for full text, please go to the a.m. URL]