Nitric oxide donor prodrug JS-K increases efficacy of repetitive irradiation in U87 cells in vitro

M. Heckler, N. Osterberg, B. Baumer & A. Weyerbrock
Objective: The fatal prognosis of glioblastoma multiforme (GBM) is based on strong radio- and chemoresistance. Nitric oxide (NO) release of the diazeniumdiolate JS-K is mediated by glutathione-S-transferases (GSTs). GBM cells overexpress GSTs, thus JS-K facilitates a targeted intracellular release of[for full text, please go to the a.m. URL]