Analysis of BRAF V600E mutation in nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

G. Schindler, D. Capper, K. Schmieder, D.N. Louis, S. Pfister & A.V. Deimling
Objective: The V600E missense mutations constitutes the vast majority of tumor-associated somatic alterations in the v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) gene. High mutation frequencies have been reported in melanoma, colon and papillary thyroid carcinoma. Of late alterations have also[for full text, please go to the a.m. URL]