Impact of p53 on RNAi of the Chromosomal Passenger Protein (CPP) survivin in glioma cells

R. Wiedemuth, G. Schackert & A. Temme
Objective: We have previously shown that RNAi of survivin blocks proliferation of malignant glioma cells in vitro and significantly inhibited growth of subcutaneous as well as orthothopic glioma xenografts [ref:1]. Survivin is involved in two main cellular processes, cell division (serving[for full text, please go to the a.m. URL]