Clinical Trial Designs for Predictive Marker Validation and Targeted Cancer Therapies

Anja Mayer-Zitarosa, Petra Schnell-Inderst, Agnes Luzak, Theresa Hunger & Uwe Siebert
Background: Cancer is a major cause of death with an increasing incidence worldwide. Targeted therapies in combination with predictive markers can increase treatment success and reduce adverse events in cancer patients. There are several ways to design trials to evaluate these test-treatment combinations[for full text, please go to the a.m. URL]