What kind of changes did the publication of two large-scale RCTs lead to in prostate cancer screening guidelines ?

C. Hamashima
Objective: Although prostate-specific antigen (PSA) screening is conducted worldwide, its effectiveness in reducing mortality from prostate cancer has remained controversial. In 2009, intermediate results from the European Randomized Study of Screening for Prostate Cancer (ERSPC) and the Prostate, Lung,[for full text, please go to the a.m. URL]