The experience with GRADE in a national clinical practice guideline: practical issues around risk of bias and safety

J. López-Alcalde, B. Nieto, J. Gracia, M. Miravitlles & J.A. Blasco
Background: We used GRADE to develop a clinical practice guideline (CPG) on chronic obstructive pulmonary disease in the context of the National CPG Program in Spain (GuiaSalud). Objectives: To identify methods used in the development of a CPG with GRADE for assessment of the risk of bias (RoB) of[for full text, please go to the a.m. URL]