The challenges of using GRADE methodology with prognostic studies-a case study of managing an acute painful sickle cell episode in hospital

A. Senthinathan, T. Tan, D. Jones, P. Alderson & E. McFarlane
Background: GRADE (Grading of Recommendations Assessment, Development and Evaluation) provides a structured approach to presenting outcomes from systematic reviews addressing intervention and diagnostic questions and allows explicit judgements about the overall quality of the evidence. However, there[for full text, please go to the a.m. URL]