Dysregulated expression of proteinase inhibitor in the pathogenesis of chronic rhinosinusitis

Kai Fruth, Gyula Göbel, Jan Gosepath, Irene Schmidtmann, Wolf J. Mann & Jürgen Brieger
Background: Chronic Rhinosinusitis is a multifactorial disease. An altered epithelial function might be one of the factors contributing to the pathophysiology of chronic rhinosinusitis. Spink5 is a protease inhibitor and supposed to be an essential regulator of epithelial integrity. The role of spink5[for full text, please go to the a.m. URL]