Temporal onset pattern of Cre recombinase under promotor Brn3.1 in hair cells

Silke Frenz, Katja John, Kristen Rak, Sibylle Jablonka, Rudolf Hagen & Robert Mlynski
Several mouse mutant strains serve as models of human hearing disorders. Unfortunately, germ line mutation of a gene that is expressed in many tissues and many cell types often results in embryonic lethality. Cre recombinase mediated tissue-specific gene targeting is a powerful tool for studying development[for full text, please go to the a.m. URL]