Postoperative Ileus is mediated via IL1 signaling acting on enteric glial cells

Burkhard Stoffels, Kristoph J. Hupa, Susanne A. Snoek, Sjoerd Van Bree, Jörg C. Kalff, Wouter J. De Jonge & Sven Wehner
Introduction: Postoperative ileus (POI) is a common consequence of intestinal surgery that enhances morbidity and hospitalization, but its etiology is unclear. In the present study we investigated if and how TLRs as well as IL-1-dependent pathways contribute to the onset of POI as well as the resolution.[for full text, please go to the a.m. URL]