Identification of a microRNA expression signature for radiochemosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g

Junius Salendo, Melanie Spitzner, Frank Kramer, Peter Jo, Tim Beissbarth, Hendrik Wolff, Heinz Becker, Matthias Dobbelstein, B. Michael Ghadimi, Marian Grade & Jochen Gaedcke
Introduction: Preoperative 5-fluorouracil-based chemoradiotherapy is the standard treatment for locally advanced rectal carcinomas.However, the individual tumor response is very heterogeneous,ranging from complete resistance to regression. Therefore, ascertaining the role of microRNAs (miRNAs)in therapy[for full text, please go to the a.m. URL]