Fibronectin extra domain B (ED-B) directed Anticalins for the localization and grading of gliomas in histology and molecular imaging

Valerie Albrecht, Peter Bartenstein, Jörg-Christian Tonn, Christian Schichor, Arne Skerra & Rainer Glaß
Objective: The fibronectin extra domain B (ED-B) is an alternative splice variant of the extracellular matrix protein fibrobection. ED-B is expressed by neonatal and neoplastic cells, but is absent from healthy adult tissue. We investigated the expression of ED-B in human glioma. Also, we explored ED-B[for full text, please go to the a.m. URL]