An epigenome-wide DNA methylation analysis of brain metastases revealed singular patterns of cancer progression

Ramon Martínez, Veit Rohde, Gabriele Schackert, Matthias Kirsch, Javier Carmona & Manel Esteller
Objective: A variety of epigenetic lesions such as global DNA hypomethylation and aberrant hypermethylation of gene promoters is associated with the pathogenesis of metastases in human cancers. These epigenetic aberrations lead to a repression of gene expression that confers cancer cells the competence[for full text, please go to the a.m. URL]