Is “less better than more” for Dll4-Notch signaling in glioblastoma multiforme?

Yuan Zhu, Nicolai El Hindy, Chao You, I. Erol Sandalcioglu & Ulrich Sure
Objective: Glioblastoma multiforme (GBM) is a highly aggressive brain tumour, characterized by massive neovascularisation and intense therapy resistance. Dll4-Notch signaling is vascular specific. Activation of this signaling has been found in various tumours and associated with the resistance to anti-VEGF[for full text, please go to the a.m. URL]