A reciprocal metabolic switch between the pentose phosphate pathway and glycolysis is induced by hypoxia versus oxygenation

Annegret Kathagen, Alexander Schulte, Gerd Balcke, Carsten Kuhl, Hauke Günther, Heidi Phillips, Manfred Westphal & Katrin Lamszus
Objective: The Warburg effect describes the metabolic switch of tumor cells away from mitochondrial ATP generation to aerobic glycolysis, which is even enhanced by hypoxia, one characteristic of glioblastomas and a well-known factor in maintaining stemness. However, O2 levels fluctuate within the tumor,[for full text, please go to the a.m. URL]