Pharmacodynamics of S-Ketamine in gyrencephalic spreading depolarizations

Edgar Santos, Renan Sanchez-Porras, Michael Schoell, Zelong Zheng, Andreas Unterberg & Oliver W. Sakowitz
Objective: Cortical spreading depolarizations are related to worse outcome in brain injury patients. Ketamine can reduce the incidence of CSDs in humans but the best administration regimen is yet unknown. The aim of this study was to characterize the effects of S-ketamine, using single i.v. bolus and[for full text, please go to the a.m. URL]