FoxM1 promotes β-Catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis

Nu Zhang, Ping Wei, Aihua Gong, Wen-Tai Chiu, Hsueh-Te Lee, Howard Colman, He Huang, Jianfei Xue, Mingguang Liu, Yong Wang, Raymond Sawaya, Keping Xie, W. K. Alfred Yung, René H. Medema, Xi He & Suyun Huang
Wnt/β-catenin signaling is essential for stem cell regulation and tumorigenesis, but its molecular mechanisms are not fully understood. Here, we report that FoxM1 is a downstream component of Wnt signaling and is critical for β-catenin transcriptional function in tumor cells. Wnt3a [for full text, please go to the a.m. URL]