The role of the disintegrin-metalloprotease ADAM8 in high-grade gliomas

Uwe Schlomann, Waldemar Schulz, Susanne Schieber, Catharina Conrad, Fangyong Dong, Axel Pagenstecher, Jörg W. Bartsch & Christopher Nimsky
Objective: ADAM proteases are important mediators of tumor growth, invasion and angiogenesis. As such, ADAM8 is of clinical significance, since glioma patient survival correlates inversely with ADAM8 expression levels. In this respect we hypothesised that ADAM8 has a therapeutic window in high-grade[for full text, please go to the a.m. URL]