Integrin alpha v beta 3 (αvβ3) expression and MGMT promoter methylation in patients with glioblastoma

Oliver Schnell, David Pfirrmann, Valerie Albrecht, Sabina Eigenbrod, Jörg-Christian Tonn & Christian Schichor
Objective: Integrin alpha v beta 3 (αvβ3) is important for invasive tumor growth and angiogenesis in glioblastomas (GBM). In GBM patients with hypermethylation of the MGMT promoter, clinical studies have demonstrated a better prognosis when integrin-inhibitors were added to concommittant[for full text, please go to the a.m. URL]