PI3Kp110delta is central in mediating EGFRvIII-dependent resistance to Erlotinib in an EGFR-amplified cell culture system

Alexander Schulte, Katrin Liffers, Adrian Merlo, Manfred Westphal & Katrin Lamszus
Objective: The objective of the current study was to identify central mediators of drug resistance in an Erlotinib-resistant, EGFR-amplified, EGFRvIII-positive in vitro- and in vivo model system. Method: BS153 cells (EGFR-amplified, EGFRvIII-positive) were maintained in the presence of the EGFR TKI[for full text, please go to the a.m. URL]