Expression profile of drug-metabolizing and drug-resistance genes in primary, secondary and recurrent human gliomas using quantitative RT-PCR

Pantelis Stavrinou, Gabriele Röhn, Arend Koch, Roland Goldbrunner & Marco Timmer
Objective: The disparate prognosis between different astrocytic tumors cannot be adequately accounted for by the classical clinical variables, and resistance to chemotherapeutic drugs is a major cause of treatment failure. The identification of drug metabolizing enzymes within the human blood-brain-barrier[for full text, please go to the a.m. URL]