Brain arteriovenous malformations and genetic polymorphisms in the Notch 4-Gene

Daniel Delev, Anna Pavlova, Johannes Oldenburg, Ralf Fimmers, Johannes Schramm & Matthias Simon
Objective: Brain arteriovenous malformations (AVM) are vascular lesions that shunt arterial blood directly into draining veins without intervening capillaries. AVMs are a frequent and important cause of intracranial hemorrhage in young adults. Little is known about the molecular genetic pathomechanisms[for full text, please go to the a.m. URL]