Behavioral and electrophysiological validation of rotenone induced rat model of Parkinson's disease

Christof Von Wrangel, Kerstin Schwabe, Joachim K. Krauss & Mesbah Alam
Objective: The 6-hydroxydopamine (6-OHDA) Parkinson (PD) rat model is based on specific dopamine depletion in the nigrostriatal pathway, which subsequently leads to hyperactivity of the subthalamic nucleus (STN). Chronic rotenone injections similarly lead to loss of dopaminergic neurons in the substantia[for full text, please go to the a.m. URL]