Changes in the Progesterone-, Estrogen-, HER2/neu-receptor status and the proliferation marker Ki-67 in metastasizing breast cancer: discordance rates and time to progression in brain metastases

Christina Cramer, Gabriele Röhn, Monika Ortmann, Roland Goldbrunner & Marco Timmer
Objective: Estrogen receptor (ER), progesterone receptor (PgR), human EGF receptor 2 (Her2) and Ki-67 are important predictive and prognostic markers for making effective treatment decisions. Moreover, changes in these factors due to relapse are seen clinically, however, the frequency and clinical significance[for full text, please go to the a.m. URL]