Endothelial EphB4 mediates vascular resistance to antiangiogenic therapy

Marcus Czabanka, Moritz Markel, Thomas Broggini, Irina Kremetskaia, Melina Nieminen & Peter Vajkoczy
Objective: Antitumor effects of Anti-VEGF treatment are limited by vascular resistance mechanisms. Pericyte-endothelial cell interactions are important mediators of vascular survival mechanisms. EphrinB2-EphB4 interactions induce pericyte-endothelial interactions. It was the aim of our study to analyze[for full text, please go to the a.m. URL]