The sphingosine-1-phosphate analogon FTY720 has potent antiproliferative effects on glioblastoma cell line

Malgorzata Kolodziej, B. Al-Barim, Marco Stein, Marcus Reinges, Eberhard Uhl & K. Quint
Objective: The sphingosine-1-phosphate (S1P) pathway is involved in cell survival, growth, migration and angiogenesis. While overexpressed in gliomas, we and others have previously shown the influence of sphingosne kinase 1 and S1P-receptor 1 expression on survival of glioma patients. Here we investigate[for full text, please go to the a.m. URL]