CAIX regulates extracellular pH and invasion in glioblastoma

Martin Andreas Proescholdt, Marsha Merrill, Eva-Maria Stoerr, Annette Lohmeier & Alexander Brawanski
Objective: Malignant gliomas are highly invasive tumors. Metabolically these tumors are characterized by glycolysis leading to increased levels of lactic acid. The hypoxia-inducible carbonic anhydrase (CA) IX has been shown to moderate the extrusion of hydrogen ions into the extracellular space. Since[for full text, please go to the a.m. URL]